The upcoming Virginia Comic-Con (or Central Virginia Comic-Con, depending on where you look on their web pages) will be on November 23rd, 2008 (the weekend before Thanksgiving). It's out of the DC metro area proper, but still within reasonable driving distance (depending on where in the region you are, I suppose!). I've never been, but it looks to be a reasonably small show, but with a decent guest list this year!
Special Guests include the Tsunami Studios gang (Rick Ketcham, Randy Green, Steve, Bird, John Wycough, Kelly Yates, and Brian Shearer). James Kuhoric (his only convention appearance this year), local yokel Steve Conley, Jason Craig, Louis Small Jr., and small press creators Martin Krause, Brian Vissagio, and Dan Nokes of 21st Century Sandshark Studios.
Their vendor list looks similar to the one you find at the Capital Associates show in Tyson's Corner -- Tomorrow's Treasures, Cards Comics and Collectibles, Richmond Comix, Dino Thore, Guy Rose, Dave Shankle, FanData Comics, Banks' Comics, Rick Fortenberry, Battlefield Comics, Brett's Comic Pile, New World, Kuti's Comics, All-American Comics, West End Comics, Heroes Aren't Hard to Find, Kupinski's Comics, Wonder Wares, Zeno's Comics, and Dominion Comics. Some names there that don't ring a bell though, so you're bound to find something you haven't seen before or are looking for that the "usual suspects" haven't had.