Chris Shields runs cIndy Center, a podcast that frequently deals with comics. DC-based Chris interviews cartoonists (as well as other types of artists) and releases the interviews as podcasts on a regular basis. You can subscribe to Chris's podcast through itunes or sign up at his website.
Recent interviews of cartoonists include Mark Millar, Fred Hembeck (a real favorite of mine), and Zak Smith (the artist who illustrated Pynchon's Gravity's Rainbow sort of as a graphic novel).
2nd in a series of profiles on local comics bloggers.