Their website has all the information. Including a pretty complex schedule.
And here's how they describe it:
Otakon is the convention of the otaku generation: by fans, for fans; and we're back for our 17th year in 2010!
Join thousands of your fellow fans as we descend on Baltimore to celebrate all anime, manga, and all facets of Asian pop culture!
Ever since 1999, we've taken over a sizable chunk of Baltimore's Inner Harbor for a 3-day festival celebrating the pop culture that's brought us everything from Astroboy to Yu-Gi-Oh, from the Seven Samurai to Spirited Away.