Cathy Guisewite is retirng her strip Cathy. I've seen this comment more than once now, and here's Tom Spurgeon articulating it the best:
I urge every paper that is looking for a replacement to consider Cul-De-Sac. I think it's the finest strip going with a client list short of where it should be, but it really needs to sit in your paper for a while to have the best chance for people to pick up on its rhythms. It's not the kind of strip that benefits from replacing something that's been running and that has fans that could demand its return.